Protein Details: Amiloride-sensitive sodium channel subunit alpha
Protein ID
ICDB_Pro_0147
Protein Name
Amiloride-sensitive sodium channel subunit alpha
Gene Name
scnn1a; enacalpha
Organism
Neoceratodus forsteri (Australian lungfish) (Ceratodus forsteri)
Length
655 amino acids
AlphaFoldDB
AF-H1AFJ5-F1-model_v4.pdb
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus.
Sequence
MTDKEEEAEGGKKKEPMIGFYDSYQELFEFFCNNTTIHGTIRMVCSKHNNMKTVSWTILFITTFGVMYWQFGLLLGQYYSYPVSITMSVNFDKLIFPAVTVCTLNPYRYNVVSTQLANLDCYTEELLSTLYHYNPLTSGNQSACNSSSTAGTRAFDESYMKLEFLNDENTAYSGPVKGATNSTSPVNHTEFYRIGFKLCNATGEDCFYQTYSSGVDALREWYKFQYINIMAQIPSQSNQEDDSQISNFVYACEFNKVSCGVENYTRFRHPVYGNCYTYNDGQSATPWASFVPGVGNGLSLVLRTEQNDFLPFLSTVAGARVLVHDQNQPPFMEDSGLDIRPGVETSIGMKKEIISRLGGVYGNCTDGSDIDVVNLYNSDYNQQACVRSCFQATIVQQCGCGYYFYPLPSGAEYCSYSRNKSWGYCYYKLYKAFAADELGCFRRCRKPCQYTDYKMTAGYAQWPSSVSESWITSILSQENQYNMTSGRKNIAKLNVYFYELNYQTMGESPSFTVVTLLSNMGSQWSLWFGSSVLSVVEMGELVFDLIAVGVIVLRRRRREKCQASSDGEGTSDSTAGTHRGQENASRSGRDVACNRFVVVAEISPPPAYDTLQLDVPVACAPDCECTQHVSHASVHSQAPCSSQPEQEASEGPTVL
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Strongly expressed in gill; kidney and rectum (at protein level). More weakly expressed in muscle; brain; heart; liver and intestine.
DOI ID
10.1098/rspb.2012.1945